(Thành phần để điều trị bệnh phổi nghề nghiệp bao gồm Aicar có khả năng phục hồi viêm và quá mẫn cảm đường hô hấp)
PURPOSE: A composition for occupational lung disease treatment including AICAR is provided to reduce production of reactive oxygen species(ROS) and increased NF-kB activities, thereby preventing and improving the occupational lung disease.
CONSTITUTION: A composition for occupational lung disease treatment includes AICAR(5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside) as an active ingredient, a carrier, excipient, and diluents, and is formulated as pharmaceutical unit dose form. The composition is administered in effective amount of 50-100mg/kg. The occupational lung disease is an occupational asthma and induced by toluene diisocyanate(TDI). The AICAR is an active factor of AMP-activated protein kinase(AMPK) and can be administered in any method but preferably intraperitoneal administration. The composition can be used for dietary supplement by adding edible additives other than AICAR, and the additives have no certain restriction.